AbstractNanotechnology is widely used in several industrial and consumer sectors and has the potential to grow further and expand globally. An exploration of stakeholder (SH)’s perceptions is essential to ensuring that robust risk governance processes are in place for nanotechnology and nano-related products. In response, numerous studies have been conducted to investigate SH’s perceptions of nanotechnology and nano-related products over the past 15 years. To build on this work and to capture current perceptions across a wide panel of SHs, we conducted a multi-national and cross-sectoral SH study of awareness, perceptions and opinions regarding the use and potential impact on society and the environment of nanomaterials (NMs) and nano-related products, and SH’s expectations about risk governance. The study was conducted using both quantitative and qualitative inquiries and targeted more than 3000 SHs across different sectors in a total of 15 countries. Results showed a tendency towards more convergence of opinions amongst all the relevant SHs and the public respondents than in past studies. There was consensus on the crucial importance of having unbiased, scientific and trustable information regarding the potential impacts of NMs and nano-related products on the environment, health and safety. SHs were interested in having more internationally harmonised and robust regulation for NMs and nano-related products; improved scientific evidence on nanomaterial hazards, exposures and effects; as well as specific guidance on the safe use of NMs. Overall, this work provides an updated scenario of SHs’ perceptions regarding nanotechnology and nano-related products, underscoring the importance of including SH needs in effective risk governance strategies.