Synthesis of New Cisplatin Derivatives from Bile Acids
Journal article published in 2020 by
Barbara Seroka 
,
Zenon Łotowski,
Agnieszka Hryniewicka ,
Lucie Rárová,
Rafal R. Sicinski,
Aneta M. Tomkiel,
Jacek W. Morzycki
,
Zenon Łotowski,
Agnieszka Hryniewicka ,
Lucie Rárová,
Rafal R. Sicinski,
Aneta M. Tomkiel,
Jacek W. Morzycki
This paper is made freely available by the publisher.
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Abstract
A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.