Canada is facing a national opioid overdose epidemic, with deaths due to opioid overdoses continuing to rise dramatically. To that end, the opioid experiences of the Kingston, Frontenac, and Lennox and Addington communities, the regional hub for southeastern Ontario and the home of Queen’s University, may provide meaningful insights. This article provides a description of recent activities to address the local opioid crisis, a rationale for their adoption and the context in which they are being undertaken.