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American Association for the Advancement of Science, Science, 6436(364), p. 148-153, 2019

DOI: 10.1126/science.aav7942

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Structure and dynamics of the active human parathyroid hormone receptor-1

Journal article published in 2019 by Li-Hua Zhao ORCID, Shanshan Ma ORCID, Ieva Sutkeviciute ORCID, Dan Shen ORCID, X. Edward Zhou ORCID, Parker W. de Waal ORCID, Chen-Yao Li ORCID, Yanyong Kang, Lisa J. Clark ORCID, Frederic G. Jean-Alphonse ORCID, Alex D. White ORCID, Dehua Yang ORCID, Antao Dai ORCID, Xiaoqing Cai ORCID, Jian Chen ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Bone-cell regulation, fleshed out One of many medically relevant G protein–coupled receptors, parathyroid hormone receptor-1 (PTH1R) functions in the control of calcium homeostasis and bone physiology. Zhao et al. used cryo–election microscopy to observe the structure of PTH1R in a complex with a modified form of parathyroid hormone and stimulatory G protein. The structural model helps explain how parathyroid hormone interacts with its receptor and the molecular basis for receptor activation. Science , this issue p. 148