Grape bark from the wine industry still contains significant amounts of phenolic compounds. Specific characteristics of the applied solvents influence the extraction of phenolic compounds directly. This study aimed to evaluate the influence of different solvents obtaining phenolic compounds in Syrah grape barkextracts by High-Performance Liquid Chromatography (HPLC). Grape peel extracts were prepared with three different solvents (water, 50%, and 80% grain alcohol), and evaluated using standard curve with 15 phenolic compounds. It was not possible to quantify the phenolic compounds, but the chromatogramssuggest the presence of some of them. The solvent that provided the best interaction with grape peel was 50% grain alcohol.