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Nature Research, npj Science of Food, 1(4), 2020

DOI: 10.1038/s41538-020-0063-7

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Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

Journal article published in 2020 by Yu Toyoda ORCID, Tappei Takada ORCID, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Naoyuki Kobayashi, Youichi Tsuchiya, Hiroshi Suzuki
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractAs hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.