Published in
American Association for the Advancement of Science, Science Translational Medicine, 494(11), 2019
DOI: 10.1126/scitranslmed.aau6246
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Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition
Journal article published in 2019 by
Roger A. Habets 
,
Charles E. de Bock ,
Lutgarde Serneels ,
Inge Lodewijckx,
Delphine Verbeke ,
David Nittner ,
Rajeshwar Narlawar ,
Sofie Demeyer ,
James Dooley ,
Adrian Liston ,
Tom Taghon ,
Jan Cools ,
Bart de Strooper
,
Charles E. de Bock ,
Lutgarde Serneels ,
Inge Lodewijckx,
Delphine Verbeke ,
David Nittner ,
Rajeshwar Narlawar ,
Sofie Demeyer ,
James Dooley ,
Adrian Liston ,
Tom Taghon ,
Jan Cools ,
Bart de Strooper
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Abstract
Selective inhibition of γ-secretase complexes targets T-ALL without the dose-limiting side effects of complete γ-secretase inhibition.