Published in
American Association for the Advancement of Science, Science Translational Medicine, 476(11), 2019
DOI: 10.1126/scitranslmed.aat1199
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Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin
Journal article published in 2019 by
Christopher N. Toepfer 
,
Hiroko Wakimoto ,
Amanda C. Garfinkel ,
Barbara McDonough ,
Dan Liao,
Jianming Jiang ,
Angela C. Tai,
Joshua M. Gorham ,
Ida G. Lunde ,
Mingyue Lun,
Thomas L. Lynch ,
James W. McNamara ,
Sakthivel Sadayappan,
Charles S. Redwood ,
Hugh C. Watkins
and other authors.
,
Hiroko Wakimoto ,
Amanda C. Garfinkel ,
Barbara McDonough ,
Dan Liao,
Jianming Jiang ,
Angela C. Tai,
Joshua M. Gorham ,
Ida G. Lunde ,
Mingyue Lun,
Thomas L. Lynch ,
James W. McNamara ,
Sakthivel Sadayappan,
Charles S. Redwood ,
Hugh C. Watkins
and other authors.
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Abstract
Mutations in MYBPC3 disrupt myosin states of relaxation, and manipulating myosin therapeutically abates the effects of MYBPC3 mutations.