Published in
American Association for the Advancement of Science, Science Translational Medicine, 503(11), 2019
DOI: 10.1126/scitranslmed.aau0164
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Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice
Journal article published in 2019 by
Xin Tang 
,
Jesse Drotar,
Keji Li ,
Cullen D. Clairmont ,
Anna Sophie Brumm,
Austin J. Sullins ,
Hao Wu,
Xiaoxiao Shawn Liu,
Jinhua Wang,
Nathanael S. Gray,
Mriganka Sur ,
Rudolf Jaenisch
,
Jesse Drotar,
Keji Li ,
Cullen D. Clairmont ,
Anna Sophie Brumm,
Austin J. Sullins ,
Hao Wu,
Xiaoxiao Shawn Liu,
Jinhua Wang,
Nathanael S. Gray,
Mriganka Sur ,
Rudolf Jaenisch
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Abstract
KCC2 expression–enhancing small molecules rescue cellular and behavior deficits in human RTT neurons and Mecp2 mutant mice.