Published in
American Association for the Advancement of Science, Science Advances, 4(5), 2019
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Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
Journal article published in 2019 by
R. Filograna,
C. Koolmeister 
,
M. Upadhyay ,
A. Pajak ,
P. Clemente,
R. Wibom,
M. L. Simard ,
A. Wredenberg,
C. Freyer,
J. B. Stewart ,
N. G. Larsson
,
M. Upadhyay ,
A. Pajak ,
P. Clemente,
R. Wibom,
M. L. Simard ,
A. Wredenberg,
C. Freyer,
J. B. Stewart ,
N. G. Larsson
This paper is made freely available by the publisher.
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Abstract
The severity of mitochondrial disease caused by mutations of mtDNA does depend on the absolute amount of wild-type mtDNA.