Published in
American Association for the Advancement of Science, Science Signaling, 601(12), 2019
DOI: 10.1126/scisignal.aay0482
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HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Journal article published in 2019 by
Hilary E. Nicholson 
,
Zeshan Tariq,
Benjamin E. Housden,
Rebecca B. Jennings ,
Laura A. Stransky,
Norbert Perrimon ,
Sabina Signoretti ,
Isaac S. Harris,
Jennifer E. Endress,
William G. Kaelin
,
Zeshan Tariq,
Benjamin E. Housden,
Rebecca B. Jennings ,
Laura A. Stransky,
Norbert Perrimon ,
Sabina Signoretti ,
Isaac S. Harris,
Jennifer E. Endress,
William G. Kaelin
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Abstract
Blocking the kinases CDK4 and CDK6 may be a more broadly applicable therapy for patients with ccRCC.