Published in
American Association for the Advancement of Science, Science Immunology, 42(4), 2019
DOI: 10.1126/sciimmunol.aay8556
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T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage
Journal article published in 2019 by
S. Takashima 
,
M. L. Martin ,
S. A. Jansen ,
Y. Fu,
J. Bos,
D. Chandra ,
M. H. O’Connor ,
A. M. Mertelsmann,
P. Vinci,
J. Kuttiyara ,
S. M. Devlin,
S. Middendorp ,
M. Calafiore ,
A. Egorova,
M. Kleppe
and other authors.
,
M. L. Martin ,
S. A. Jansen ,
Y. Fu,
J. Bos,
D. Chandra ,
M. H. O’Connor ,
A. M. Mertelsmann,
P. Vinci,
J. Kuttiyara ,
S. M. Devlin,
S. Middendorp ,
M. Calafiore ,
A. Egorova,
M. Kleppe
and other authors.
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Abstract
T cell–derived interferon-γ can directly target intestinal stem cells to induce their apoptosis in a JAK/STAT-dependent manner (see the related Focus by Kretzschmar and Clevers ).