Published in
American Association for the Advancement of Science, Science Signaling, 596(12), 2019
DOI: 10.1126/scisignal.aaw3469
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SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
Journal article published in 2019 by
John Rizk 
,
Joseph Kaplinsky ,
Rasmus Agerholm,
Darshana Kadekar,
Fredrik Ivars,
William W. Agace,
W. Wei-Lynn Wong ,
Matthew J. Szucs,
Samuel A. Myers,
Steven A. Carr ,
Ari Waisman ,
Vasileios Bekiaris
,
Joseph Kaplinsky ,
Rasmus Agerholm,
Darshana Kadekar,
Fredrik Ivars,
William W. Agace,
W. Wei-Lynn Wong ,
Matthew J. Szucs,
Samuel A. Myers,
Steven A. Carr ,
Ari Waisman ,
Vasileios Bekiaris
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Abstract
By promoting noncanonical NF-κB signaling, SMAC mimetics can reprogram CD4 + T helper cell differentiation and curb autoimmunity.