Published in
American Association for the Advancement of Science, Science Signaling, 563(12), 2019
DOI: 10.1126/scisignal.aau0240
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Phosphorylation of the phosphatase PTPROt at Tyr <sup>399</sup> is a molecular switch that controls osteoclast activity and bone mass in vivo
Journal article published in 2019 by
Lee Roth 
,
Jean Wakim ,
Elad Wasserman ,
Moran Shalev ,
Esther Arman,
Merle Stein ,
Vlad Brumfeld,
Cari A. Sagum ,
Mark T. Bedford ,
Jan Tuckermann ,
Ari Elson
,
Jean Wakim ,
Elad Wasserman ,
Moran Shalev ,
Esther Arman,
Merle Stein ,
Vlad Brumfeld,
Cari A. Sagum ,
Mark T. Bedford ,
Jan Tuckermann ,
Ari Elson
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Abstract
A phosphoswitch in the tyrosine phosphatase PTPROt determines whether it stimulates or inhibits the kinase Src.