Published in
Royal Society of Chemistry, Chemical Science, 4(11), p. 1122-1131, 2020
DOI: 10.1039/c9sc04189c
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Chemical modification of the adeno-associated virus capsid to improve gene delivery
Journal article published in 2020 by
Mathieu Mével 
,
Mohammed Bouzelha,
Aurélien Leray,
Simon Pacouret,
Mickael Guilbaud,
Magalie Penaud-Budloo,
Dimitri Alvarez-Dorta,
Laurence Dubreil,
Sébastien G. Gouin ,
Jean Philippe Combal,
Mirja Hommel,
Gloria Gonzalez-Aseguinolaza,
Véronique Blouin,
Philippe Moullier,
Oumeya Adjali
and other authors.
,
Mohammed Bouzelha,
Aurélien Leray,
Simon Pacouret,
Mickael Guilbaud,
Magalie Penaud-Budloo,
Dimitri Alvarez-Dorta,
Laurence Dubreil,
Sébastien G. Gouin ,
Jean Philippe Combal,
Mirja Hommel,
Gloria Gonzalez-Aseguinolaza,
Véronique Blouin,
Philippe Moullier,
Oumeya Adjali
and other authors.
This paper is made freely available by the publisher.
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Abstract
Bioconjugated AAV vectors, achieved by coupling of ligands on amino groups of the capsid, are of great interest for gene delivery. Chemical modifications can be used to enhance cell tropism and to decrease interactions with neutralizing antibodies.