In this experimental study the influence of fissuring orientation and confinement pressure on the mechanical behaviour of natural clays is investigated. The tested material, the scaly clay from Santa Croce di Magliano (south of Italy), is characterised by an intense network of pre-existing fissures of single orientation. Several plane strain compression tests have been conducted, under different confinement pressures (i.e., from 50 to 600 kPa), on specimens having fissures with vertical, medium and horizontal inclination. Digital Image Correlation has been used to follow the deformation processes of the specimens throughout the tests by measuring incremental shear and volumetric strain maps. The results showed a strong coupling between the total confinement and the fissure inclination, that is controlling both the onset and the development of the patterns of the localisation processes. The new results have been compared with previous ones carried out on the same material without confinement. The comparison shed light on the role of total confinement that becomes particularly relevant from certain levels of pressures and fissuring inclination.