Published in
American Association for the Advancement of Science, Science Translational Medicine, 470(10), 2018
DOI: 10.1126/scitranslmed.aah3924
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A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
Journal article published in 2018 by
Marcel Maier 
,
Tobias Welt ,
Fabian Wirth,
Fabio Montrasio ,
Daniel Preisig,
Jordan McAfoose,
Fernando G. Vieira ,
Luka Kulic ,
Claudia Späni ,
Thilo Stehle,
Steve Perrin,
Markus Weber,
Christoph Hock,
Roger M. Nitsch,
Jan Grimm
,
Tobias Welt ,
Fabian Wirth,
Fabio Montrasio ,
Daniel Preisig,
Jordan McAfoose,
Fernando G. Vieira ,
Luka Kulic ,
Claudia Späni ,
Thilo Stehle,
Steve Perrin,
Markus Weber,
Christoph Hock,
Roger M. Nitsch,
Jan Grimm
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Abstract
A human-derived antibody that is selective for misfolded SOD1 decreases motor impairments and boosts survival in several rodent models of ALS.