In the current scenario of resistance of weeds to glyphosate in grain and fiber production systems, imidazolinone-resistant soybean is shown as an option in the rotation of biotechnology events and herbicide action mechanisms through the application of [imazapic+imazapyr]. However, due to its persistence in the soil, the herbicide may harm the subsequent crop. The objective of this work was to evaluate the residual activity of the herbicide [imazapic+imazapyr] applied in pre-emergence in soybean cultivation on cotton in succession. The experimental design was a randomized block design with five replicates, using seven concentrations (0; 6.25; 12.5; 25; 50; 100 and 200%) of the recommended dosage of the herbicide [imazapic+imazapyr] ([78,75+26,25] g ha-1). The cotton was sown 112 days after application of the herbicide with accumulated rainfall of 637 mm during the soybean cycle, totalizing 1,043 mm until the cotton harvest. There was no significant difference for the analyzed variables. It is concluded that the BRS 8482cv soybean cultivar is resistant to double of the recommended dosage ([157.5+52.5] g ha-1) of [imazapic+imazapyr], and its residual soil activity does not affect cotton cv. TMG 42 WS, in the 112 day interval between pre-emergence herbicide application in soybean cultivation and sowing of cotton.