American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(64), 2020
DOI: 10.1128/aac.02102-19
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The ex vivo bactericidal activity and pharmacodynamics of fosfomycin in urine were evaluated in 18 healthy subjects. Subjects received 3 g every other day (QOD) for 3 doses and then every day (QD) for 7 doses or vice versa. Serial urine samples were collected before and up to 24 h after dosing on days 1 and 5. Eight bacterial strains with various genotypic and phenotypic susceptibilities to fosfomycin were used for all experiments (5 Escherichia coli , 2 Klebsiella pneumoniae , and 1 Proteus mirabilis ).