Published in

Acta Brasiliensis, 1(4), p. 49, 2020

DOI: 10.22571/2526-4338249

Links

Tools

Export citation

Search in Google Scholar

Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

Journal article published in 2020 by Gracielle Oliveira Sabbag Cunha ORCID, Ana Paula Terezan ORCID, Andreia Pereira Matos ORCID, Marcela Carmen De Melo Burger ORCID, Paulo Cezar Vieira ORCID, João Batista Fernandes ORCID, Maria Fátima Das Graças Fernandes da Silva ORCID, Antônio Carlos Severo Menezes ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Full text: Unavailable

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.