American Society for Cell Biology, Molecular Biology of the Cell, 2(34), 2023
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Caydasi et al. identified the SWR1 chromatin-remodeling complex (SWR1-C) among novel factors that are essential for the integrity of the spindle position checkpoint (SPOC). They show that cells lacking SWR1-C activate the SPOC upon spindle misorientation but undergo mitotic slippage due to the inability of holding a prolonged SPOC arrest.