Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Asquith, Cr; Meli, Ml; Konstantinova, Ls; Laitinen, Tuomo; Peräkylä, Mikael; Poso, Antti; Rakitin, Oa; Allenspach, Karin; Hofmann-Lehmann, Regina; Hilton, St

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Elsevier, Bioorganic and Medicinal Chemistry Letters, 12(24), p. 2640-2644, 2014

DOI: 10.1016/j.bmcl.2014.04.073

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Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Journal article published in 2014 by Cr Asquith, Ml Meli, Ls Konstantinova, Tuomo Laitinen, Mikael Peräkylä, Antti Poso, Oa Rakitin

, Karin Allenspach, Regina Hofmann-Lehmann, St Hilton

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Abstract

A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.

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Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Abstract