Published in

Nature Research, Nature Reviews Microbiology, 2(9), p. 131-137, 2010

DOI: 10.1038/nrmicro2478

Links

Tools

Export citation

Search in Google Scholar

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

Journal article published in 2010 by Marnix H. Medema, Rainer Breitling ORCID, Roel Bovenberg, Eriko Takano
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

One of the most promising applications of synthetic biology is the biosynthesis of new drugs from secondary metabolites. Here, we survey a wide range of strategies that control the activity of biosynthetic modules in the cell in space and time, and illustrate how these strategies can be used to design efficient cellular synthetic production systems. Re-engineered versions of secondary metabolite biosynthetic pathways identified from any genomic sequence can then be inserted into these systems in a plug-and-play fashion. ?? 2011 Macmillan Publishers Limited. All rights reserved.