Introduction: Interventions are needed to improve stroke literacy and secondary prevention. We developed a video to educate patients hospitalized with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). Hypothesis: In a prospective trial, we hypothesized that a stroke video would improve stroke literacy in AIS and ICH patients. Methods: A 5-minute stroke education video was shown to AIS and ICH patients admitted to our service from 3/15 to 6/15. Demographics and a cognitive screen (5-min MoCA) were collected. Questions, related to stroke knowledge (n=8), self-efficacy (n=1) and patient satisfaction (n=1), were answered before, after, and 30 days after the video. Results: Among 295 screened, 102 patients were enrolled (Table 1). There was a significant difference between pre-video median knowledge score of 6 (IQR 4-7) and the post-video score of 7 (IQR 6-8; p<0.001) and between pre-video and the 30 day score of 7 (IQR 5-8; p=.04). There was a significant difference between the proportion of patients who were “very certain” in recognizing symptoms of a stroke pre- and post-video, which was maintained at 30-days (36% vs. 53%, p=0.001; 36% vs. 56%, p=0.08). The proportion who were “very satisfied” with their stroke education post-video (74%) was significantly higher than pre-video (49%, p=0.001), and this was maintained at 30 days (75%, p=0.004). There was no association between 5-min MoCA scores and stroke knowledge acquisition pre- and post-video scores, p=0.53) or stroke knowledge retention post-video and 30-day scores, p=0.95). MoCA scores correlated with pre-, post- and 30-day knowledge scores (r=0.41, p<0.001; r=0.47, p<0.001; r=0.40, p=0.003). Potential associations between stroke knowledge and behavioral changes will be reported. Conclusion: A stroke educational video was associated with improved stroke knowledge, certainty in recognizing stroke symptoms and satisfaction with stroke education. A randomized trial is planned.