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American Society for Microbiology, Applied and Environmental Microbiology, 13(79), p. 4159-4163, 2013

DOI: 10.1128/aem.00546-13

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Repression of Antibiotic Downregulator WblA by AdpA in Streptomyces coelicolor

Journal article published in 2013 by Han-Na Lee, 김응수, Jin-Su Kim, Pil Kim ORCID, Heung-Shick Lee, Eung-Soo Kim
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor was found to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor .