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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(57), p. 3398-3401, 2013

DOI: 10.1128/aac.00215-13

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BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

Journal article published in 2013 by Nicholas G. Brown ORCID, Dar-Chone Chow, Timothy Palzkill
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT β-Lactamase inhibitory protein II (BLIP-II) is a potent inhibitor of class A β-lactamases. KPC-2 is a class A β-lactamase that is capable of hydrolyzing carbapenems and has become a widespread source of resistance to these drugs for Gram-negative bacteria. Determination of association and dissociation rate constants for binding between BLIP-II and KPC-2 reveals a very tight interaction with a calculated ( k off / k on ) equilibrium dissociation constant of 76 fM (76 × 10 −15 M).