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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(57), p. 3392-3394, 2013

DOI: 10.1128/aac.00646-13

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Efficacy of Tigecycline Alone and in Combination with Gentamicin in the Treatment of Experimental Endocarditis Due to Linezolid-Resistant Enterococcus faecium

Journal article published in 2013 by Konstantinos Pontikis, Angelos Pefanis, Thomas Tsaganos, Ira-Maria Tzepi, Dionyssia-Pinelopi Carrer, Helen Giamarellou ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium . Tigecycline-treated animals had a 2.8-log 10 -CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.