Little information is available on the trends of adherence to the Mediterranean dietary pattern (MDP). This study investigates food consumption trends from 2010 to 2016 in subjects living in Northern Italy. A cross-sectional study of 8584 subjects enrolled between January 2010 and December 2016 was conducted. Socio-demographic, nutrition and lifestyle characteristics were collected. A 14-item questionnaire was used to evaluate adherence to MDP. Multivariable Poisson regression was used to evaluate the trends of and the determinants for the adherence to MDP. The overall prevalence of adherence to MDP was 14% and the trend remained constant over the six years. However, there was a marked increase in nuts consumption and a slight one in white meat consumption. Furthermore, we observed a decrease in the consumption of fruit, red meat, sweets and sugar-sweetened beverages and in the use of soffritto. Finally, higher education, being older, married, physically active, and ex-smoker was associated with greater adherence to MDP, whereas the prevalence of adherence was lower in the obese. In conclusion, the consumption of some Mediterranean and non-Mediterranean food groups changed over the six years. However, overall, the prevalence of adherence to MDP did not change. Additional strategies promoting healthy dietary habits are needed.