Published in
American Society of Hematology, Blood Advances, 1(4), p. 87-99, 2020
DOI: 10.1182/bloodadvances.2019000488
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Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells
Journal article published in 2020 by
Karen Phaik Har Lim,
Paul Milne,
Michael Poidinger,
Kaibo Duan,
Howard Lin 
,
Naomi McGovern ,
Harshal Abhyankar,
Daniel Zinn,
Thomas M. Burke ,
Olive S. Eckstein ,
Rikhia Chakraborty,
Amel Sengal,
Brooks Scull,
Evan Newell,
Miriam Merad
and other authors.
,
Naomi McGovern ,
Harshal Abhyankar,
Daniel Zinn,
Thomas M. Burke ,
Olive S. Eckstein ,
Rikhia Chakraborty,
Amel Sengal,
Brooks Scull,
Evan Newell,
Miriam Merad
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsTranscriptional profile of LCH CD1a+CD207+ DCs is most closely related to that of CD1c+ mDCs in the blood. Lineage tracing with BRAFV600E and HLA-DQB2 expression supports CD1c+ mDCs as precursors to LCH CD1a+CD207+ DCs.