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American Association for the Advancement of Science, Science Advances, 5(5), 2019

DOI: 10.1126/sciadv.aav7574

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Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor

Journal article published in 2019 by Keni Vidilaseris ORCID, Alexandros Kiriazis, Ainoleena Turku ORCID, Ayman Khattab, Niklas G. Johansson ORCID, Teppo O. Leino ORCID, Paula S. Kiuru ORCID, Gustav Boije af Gennäs, Seppo Meri, Jari Yli-Kauhaluoma ORCID, Henri Xhaard ORCID, Adrian Goldman ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Novel inhibitors of membrane-bound pyrophosphatases unlock asymmetric conformations by binding near the exit channel.