Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells
Journal article published in 2019 by
Olivier Mansier 
,
Badr Kilani,
Amélie V. Guitart ,
Alexandre Guy,
Virginie Gourdou-Latyszenok,
Caroline Marty,
Marie Parrens,
Isabelle Plo ,
William Vainchenker ,
Chloé James
,
Badr Kilani,
Amélie V. Guitart ,
Alexandre Guy,
Virginie Gourdou-Latyszenok,
Caroline Marty,
Marie Parrens,
Isabelle Plo ,
William Vainchenker ,
Chloé James
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Abstract
Key Points PF4iCre;JAK2 V617F/WT mice develop a full MPN that mimics polycythemia vera. The PF4iCre system induces JAK2V617F mutation in a small subset of HSC.