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American Society of Hematology, Blood, 25(134), p. 2261-2270, 2019

DOI: 10.1182/blood.2019000889

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EBV microRNA-BHRF1-2-5p targets the 3′UTR of immune checkpoint ligands PD-L1 and PD-L2

Journal article published in 2019 by Alexandre S. Cristino ORCID, Jamie Nourse, Rachael A. West ORCID, Muhammed Bilal Sabdia ORCID, Soi C. Law ORCID, Jay Gunawardana ORCID, Frank Vari, Sally Mujaj, Gayathri Thillaiyampalam, Cameron Snell ORCID, Madeline Gough, Colm Keane ORCID, Maher K. Gandhi ORCID
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Abstract

This article reports a novel mechanism by which Epstein-Barr virus (EBV) microRNA (miRNA) plays a role to fine-tune the expression of LMP1-driven amplification of inhibitory checkpoint programmed death ligand 1 (PD-L1) and PD-L2 in EBV+ diffuse large B-cell lymphoma. Identification and understanding of the immune checkpoint regulation via miRNA may enable potential novel RNA-based therapies to emerge.