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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(64), 2019

DOI: 10.1128/aac.01587-19

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Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Journal article published in 2019 by Maytham Hussein, Mei-Ling Han ORCID, Yan Zhu ORCID, Qi Zhou, Yu-Wei Lin, Robert E. W. Hancock ORCID, Daniel Hoyer ORCID, Darren J. Creek ORCID, Jian Li, Tony Velkov
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combination with an aminoglycoside, amikacin, against a polymyxin-susceptible isolate of Pseudomonas aeruginosa , FADDI-PA111 (MIC = 2 mg/liter for both polymyxin B and amikacin), and a polymyxin-resistant Liverpool epidemic strain (LES), LESB58 (the corresponding MIC for both polymyxin B and amikacin is 16 mg/liter).