Published in
American Society of Hematology, Blood Advances, 24(3), p. 4202-4214, 2019
DOI: 10.1182/bloodadvances.2019000702
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Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting
Journal article published in 2019 by
Anne Slomp,
Laura M. Moesbergen,
Jia-Nan Gong,
Marta Cuenca,
Peter A. von dem Borne,
Pieter Sonneveld,
David C. S. Huang 
,
Monique C. Minnema ,
Victor Peperzak
,
Monique C. Minnema ,
Victor Peperzak
This paper is made freely available by the publisher.
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Abstract
Key PointsAmplification of 1q21 correlates with increased sensitivity to MCL-1 inhibitor S63845 in primary MM cells. Poor-prognosis MM is particularly sensitive to MCL-1 inhibition, partially independent of 1q21 amplification status.