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Royal Society of Chemistry, Chemical Science, 1(11), p. 169-179, 2020

DOI: 10.1039/c9sc04649f

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Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

Journal article published in 2020 by Julian Tu ORCID, Dennis Svatunek ORCID, Saba Parvez ORCID, Hannah J. Eckvahl ORCID, Minghao Xu ORCID, Randall T. Peterson, K. N. Houk ORCID, Raphael M. Franzini ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tetrazylmethyl groups are reported here as bioorthogonal protecting groups that are readily removed by isonitriles, establishing a valuable addition to the dissociative bioorthogonal chemistry and synthetic methodology toolboxes.