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Facultad de Humanidades y Ciencias de la Educación, Synthesis: Journal of Synthetic Organic Chemistry, 02(52), p. 304-310, 2019
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Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF3
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Abstract
A sequential multistep reaction toward 5-trifluoromethylthio-1,2,3-triazoles has been established, starting from alkynes, organoazides, S8, and (trifluoromethyl)trimethylsilane (TMSCF3). This reaction features mild conditions, easy operation, and readily available substrates.