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American Society for Microbiology, Infection and Immunity, 1(88), 2019

DOI: 10.1128/iai.00559-19

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Prominent Binding of Human and Equine Fibrinogen to Streptococcus equi subsp. zooepidemicus Is Mediated by Specific SzM Types and Is a Distinct Phenotype of Zoonotic Isolates

Journal article published in 2019 by René Bergmann, Maria-Christin Jentsch, Albrecht Uhlig, Uwe Müller, Mark van der Linden, Magnus Rasmussen, Andrew Waller ORCID, Maren von Köckritz-Blickwede, Christoph Georg Baums ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Streptococcus equi subsp. zooepidemicus is an important pathogen in horses that causes severe diseases such as pneumonia and abortion. Furthermore, it is a zoonotic agent, and contact with horses is a known risk factor. In this study, we investigated the working hypothesis that the zoonotic potential varies among S. equi subsp. zooepidemicus strains in association with differences in M-like protein-mediated binding of host plasma proteins.