IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia
Journal article published in 2019 by
Sara González-García 
,
Marta Mosquera,
Patricia Fuentes ,
Tiziana Palumbo,
Adela Escudero ,
Antonio Pérez-Martínez ,
Manuel Ramírez ,
Anne E. Corcoran ,
Maria L. Toribio
,
Marta Mosquera,
Patricia Fuentes ,
Tiziana Palumbo,
Adela Escudero ,
Antonio Pérez-Martínez ,
Manuel Ramírez ,
Anne E. Corcoran ,
Maria L. Toribio
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Abstract
Key Points IL-7R expression is a functional biomarker of T-ALL cells with leukemia-initiating potential and plays a crucial role in T-ALL pathogenesis. Targeting IL-7R–mediated signaling hampers leukemia-initiating activity and progression of human T-ALL.