BackgroundThe incidence of liver disease is increasing in the UK and primary care is a key setting where improvement in the detection and management of liver disease is required. Little is known about GPs’ understanding and confidence in detecting liver disease.AimTo explore GPs’ experiences of liver disease with a focus on early detection and interpretation of liver function tests (LFTs).Design and settingA qualitative study employing semi-structured interviews of a purposive sample of GPs from five UK primary care study sites.MethodTelephone and face-to-face interviews of GPs were undertaken. Data were analysed thematically, using a constant comparative approach.ResultsFrom a total of 25 GP interviews (N = 25), four themes were identified from the data: test-requesting behaviour, confidence and challenges in diagnosing disease, access to specialist tests, and guidance and education. Participants’ descriptions of how they request and interpret LFTs varied widely. Concern over missing diagnoses was a common reason for requesting blood tests; patients with mildly abnormal LFTs and those at risk of non-alcoholic fatty liver disease (NAFLD) were a particular cause of concern. GPs saw themselves as generalists, with a reluctance to take on specialist investigations. Guidelines promoted confidence for some clinicians, but others felt that liver disease was too complex to be amenable to simple instructions. Most felt that they did not have access to relevant, focused education on liver disease.ConclusionLiver disease is not perceived as a priority in primary care. If GPs are to take on a greater role in identification and management of liver disease, support is needed to promote awareness, knowledge, and confidence.