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National Academy of Sciences, Proceedings of the National Academy of Sciences, 47(115), p. 11923-11928, 2018

DOI: 10.1073/pnas.1811520115

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Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

Journal article published in 2018 by Christoph Allolio ORCID, Aniket Magarkar, Piotr Jurkiewicz, Katarína Baxová, Matti Javanainen ORCID, Philip E. Mason, Radek Šachl, Marek Cebecauer, Martin Hof ORCID, Dominik Horinek, Veronika Heinz, Reinhard Rachel ORCID, Christine M. Ziegler, Adam Schröfel, Pavel Jungwirth
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance The passive translocation mechanism of arginine-rich cell-penetrating peptides has puzzled the scientific community for more than 20 y. In this study we propose a hitherto unrecognized mechanism of passive cell entry involving fusion of multilamellar structures generated by the cell-penetrating peptides. The geometry of entry for this mechanism is completely different from previously suggested direct translocation mechanisms, leading to another paradigm for designing molecular carriers for drug delivery to the cell.