Published in
Oxford University Press (OUP), Brain, 11(142), p. 3398-3410, 2019
DOI: 10.1093/brain/awz297
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Glycine receptor autoantibodies disrupt inhibitory neurotransmission
Journal article published in 2019 by
Sarah J. Crisp 
,
Christine L. Dixon,
Leslie Jacobson,
Elodie Chabrol,
Sarosh R. Irani ,
M. Isabel Leite,
Guy Leschziner ,
Sean J. Slaght,
Angela Vincent,
Dimitri M. Kullmann
,
Christine L. Dixon,
Leslie Jacobson,
Elodie Chabrol,
Sarosh R. Irani ,
M. Isabel Leite,
Guy Leschziner ,
Sean J. Slaght,
Angela Vincent,
Dimitri M. Kullmann
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Abstract
Immunoglobulin G autoantibodies to glycine receptors are found in many patients with progressive encephalomyelitis with rigidity and myoclonus (PERM). Crisp et al. show that purified patient IgGs disrupt inhibitory neurotransmission in cultured motoneurons, and provide evidence for direct antagonistic actions on glycine receptors.