Published in
American Society of Hematology, Blood Advances, 23(3), p. 3962-3967, 2019
DOI: 10.1182/bloodadvances.2019000731
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Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias
Journal article published in 2019 by
Ashwin Sridharan,
Carolina D. Schinke,
George Georgiev,
Mariana Da Silva Ferreira,
Victor Thiruthuvanathan,
Ian MacArthur 
,
Tushar D. Bhagat,
Gaurav S. Choudhary ,
Srinivas Aluri ,
Jiahao Chen,
Kith Pradhan,
Yu Xia,
Maya Panjikaran,
Gregory Sims,
Chirag K. Bhagat
and other authors.
,
Tushar D. Bhagat,
Gaurav S. Choudhary ,
Srinivas Aluri ,
Jiahao Chen,
Kith Pradhan,
Yu Xia,
Maya Panjikaran,
Gregory Sims,
Chirag K. Bhagat
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Leukemia-associated mutations can be detected many years before the onset of secondary leukemias in myeloma patients. Stem and progenitor cells can act as reservoirs of mutations before the onset of secondary MDS and AML after treatment of myeloma.