IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling
Journal article published in 2019 by
Andrew N. Wilkinson 
,
Karshing Chang,
Rachel D. Kuns,
Andrea S. Henden ,
Simone A. Minnie ,
Kathleen S. Ensbey,
Andrew D. Clouston,
Ping Zhang ,
Motoko Koyama,
Juan Hidalgo ,
Stefan Rose-John ,
Antiopi Varelias ,
Slavica Vuckovic,
Kate H. Gartlan ,
Geoffrey R. Hill
,
Karshing Chang,
Rachel D. Kuns,
Andrea S. Henden ,
Simone A. Minnie ,
Kathleen S. Ensbey,
Andrew D. Clouston,
Ping Zhang ,
Motoko Koyama,
Juan Hidalgo ,
Stefan Rose-John ,
Antiopi Varelias ,
Slavica Vuckovic,
Kate H. Gartlan ,
Geoffrey R. Hill
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Abstract
Key Points DCs are the principal source of IL-6 dysregulation after alloSCT. IL-6–dependent GVHD is driven by classical signaling of IL-6R on donor T cells but is regulated by trans signaling.