Published in

Elsevier, Current Opinion in Biotechnology, (30), p. 153-160

DOI: 10.1016/j.copbio.2014.06.017

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Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses.

Journal article published in 2014 by Ce Hogwood, Dg Bracewell ORCID, Cm Mark Smales
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Chinese hamster ovary (CHO) cells are widely used for the production of biotherapeutic recombinant proteins for a range of molecules including monoclonal antibodies and Fc-fusion proteins. Regulatory requirements for the final product include the removal of host cell proteins (HCPs) to acceptable amounts (