Elsevier, Current Opinion in Biotechnology, (30), p. 153-160
DOI: 10.1016/j.copbio.2014.06.017
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Chinese hamster ovary (CHO) cells are widely used for the production of biotherapeutic recombinant proteins for a range of molecules including monoclonal antibodies and Fc-fusion proteins. Regulatory requirements for the final product include the removal of host cell proteins (HCPs) to acceptable amounts (