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Oxford University Press, Genetics, 3(165), p. 1619-1622, 2003

DOI: 10.1093/genetics/165.3.1619

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Effect of misoriented sites on neutrality tests with outgroup.

Journal article published in 2003 by Emmanuelle Baudry, Frantz Depaulis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Several neutrality tests use outgroups to infer the ancestral and derived states for polymorphism data. However, homoplasy can result in the incorrect inference of the derived variant. We show that empirically derived rates of misorientation strongly influence Fay and Wu's H-test, especially when the sample size is large.