Links

Tools

Export citation

Search in Google Scholar

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.

Journal article published in 2008 by Ys Aulchenko, Cm van Duijn, Ia Hoppenbrouwers, Sv Ramagopalan, Linda Broer ORCID, Naghmeh Jafari, Jan Hillert, Jenny Link ORCID, Wangko Lundström, Eva Greiner, A. Dessa Sadovnick, A. Dessa Sadovnick, Dirk Goossens, Christine Van Broeckhoven, Van Christine Broeckhoven and other authors.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Full text: Unavailable

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.