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Oxford University Press (OUP), Human Molecular Genetics, 5(9), p. 843-848

DOI: 10.1093/hmg/9.5.843

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Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q

Journal article published in 2000 by Lucie Robinson, Darko Turic, Victoria Webb, Derek W. Morris ORCID, Mary Duke, Michael C. O’Donovan, Kirsty Pound, Charis Milham, Elizabeth Hopkin, Shamiro Fernando, Nigel Williams, Martha Easton, Jim Stevenson, Marian Hamshere, Michael J. Owen and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Family-based association mapping was used to follow up reports of linkage between reading disability (RD) and a genomic region on chromosome 15q. Using a two-stage approach, we ascertained 101 (stage 1) and 77 (stage 2) parent–proband trios, in which RD was characterized rigorously. In stage 1, a set of eight microsatellite markers spanning the region of putative linkage was used and a highly significant association was detected between RD and a three-marker haplotype (D15S994/D15S214/D15S146: P and empirical P