Royal Society of Chemistry, Chemical Science, 46(10), p. 10789-10801, 2019
DOI: 10.1039/c9sc03445e
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We present inhibitors of drug resistant mutants of EGFR including T790M and C797S. In addition, we present the first X-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR to gain insight into their binding mode.