Published in
American Society of Hematology, Blood Advances, 22(3), p. 3729-3739, 2019
DOI: 10.1182/bloodadvances.2019000761
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The ParaHox gene Cdx4 induces acute erythroid leukemia in mice
Journal article published in 2019 by
Silvia Thoene 
,
Tamoghna Mandal,
Naidu M. Vegi,
Leticia Quintanilla-Martinez ,
Reinhild Rösler,
Sebastian Wiese ,
Klaus H. Metzeler ,
Tobias Herold ,
Torsten Haferlach,
Konstanze Döhner,
Hartmut Döhner,
Luisa Schwarzmüller,
Ursula Klingmüller ,
Christian Buske,
Vijay P. S. Rawat
and other authors.
,
Tamoghna Mandal,
Naidu M. Vegi,
Leticia Quintanilla-Martinez ,
Reinhild Rösler,
Sebastian Wiese ,
Klaus H. Metzeler ,
Tobias Herold ,
Torsten Haferlach,
Konstanze Döhner,
Hartmut Döhner,
Luisa Schwarzmüller,
Ursula Klingmüller ,
Christian Buske,
Vijay P. S. Rawat
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points CDX4 induces AEL in mice and suppresses expression of genes associated with erythroid differentiation. Mutations detectable in the Cdx4-induced AEL model occur in genes reported mutated in patients with AEL.