Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
Journal article published in 2019 by
Daniel A. Rauch,
Kevin C. Conlon,
Murali Janakiram,
Jonathan E. Brammer,
John C. Harding,
B. Hilda Ye,
Xingxing Zang,
Xiaoxin Ren,
Sydney Olson 
,
Xiaogang Cheng,
Milos D. Miljkovic ,
Hemalatha Sundaramoorthi ,
Ancy Joseph ,
Zachary L. Skidmore,
Obi Griffith
and other authors.
,
Xiaogang Cheng,
Milos D. Miljkovic ,
Hemalatha Sundaramoorthi ,
Ancy Joseph ,
Zachary L. Skidmore,
Obi Griffith
and other authors.
This paper is made freely available by the publisher.
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Abstract
The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.